Pregnenolone In the body, pregnenolone is used to make all steroid hormones. It can be used as hormonal support in multiple diseases. It is being used for fatigue and increasing energy; trauma and injuries; as well as stress and improving immunity – all systems affected by cortisol deficiency. Women use pregnenolone for lumpy breasts (fibrocystic breast disease), endometriosis, symptoms of menopause, and premenstrual syndrome (PMS). Men use it for decreased sex drive and prostate problems.